Clackson, Ph.D., president of research and advancement and chief scientific officer at ARIAD. ‘The info also display that ponatinib potently inhibits the activity of all four FGFRs at clinically achievable medication levels and provide solid rationale for ponatinib’s evaluation in patients with FGFR-driven cancers.’.. ARIAD’s ponatinib potently inhibits all FGFRs abnormally expressed in multiple cancers ARIAD Pharmaceuticals, Inc. today announced outcomes of preclinical studies on ponatinib, its investigational pan-BCR-ABL inhibitor, showing potent inhibition of most four members of the fibroblast development factor receptor family of tyrosine kinases that are abnormally expressed in multiple cancers. ARIAD scientists are presenting the info this morning at the American Association for Cancers Research Annual Meeting in Orlando, Florida.Although about 50 percent of the patients seen at the University of Chicago Hospitals are African American, less than 1 / 3 of the households who sought testing had been of African ancestry. They did concur that BRCAPRO worked equally well for African Americans as it did for other populations. ‘Irrespective of ancestry,’ the writer said, ‘early age group of medical diagnosis and a family group history of breasts and ovarian cancer are the most effective predictors of mutation position.’ Each extra case of breast cancer in a initial – or second-level relative increased the chances of a mutation by 62 %.